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These studies indicate that in rats at very high doses of p -synephrine the combination with caffeine may result in cardiovascular effects

Lack of Regulatory Oversight: Since neither compound is FDA-approved for commercial use, especially not in combination, there is no regulatory framework to ensure the safety, purity, or consistent dosing for such a stack if sourced outside of controlled clinical trials

To break down what GLP-1s are, how they work, and who they might be right for, we sat down with Britleigh Garcia, PA-C, a clinician here at Nice Healthcare whos completed a certificate program in obesity management through the American Academy of Physician Assistants and The Obesity Society